Handbook of Carcinogenic Potency and Genotoxicity Databases

CRC Press, Boca Raton, FL, 754 pages, 1997.

Editors - Lois Swirsky Gold

Department of Molecular and Cell Biology, University of California, Berkeley, and Life Sciences Division, Berkeley National Laboratory

and Errol Zeiger

Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina

Description

This reference book contains the Carcinogenic Potency Database (CPDB) published in journal articles through 1992. The book includes analyses of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) through 1994 and the general published literature through 1992. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and analyses of experimental results.

An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.

Features

• Plot of CPDB allows reader easy access to information on each of 5,000 experiments, e.g., design, target sites and tumor incidence, statistics, and carcinogenic potency
• Presents, in a single source, the NTP genetic toxicity test results for 1,500 chemicals
• Provides a table organized by target organ listing carcinogens at each site in rats, mice, hamsters, monkeys, and dogs
• Provides a summary table, by chemical, of results on positivity and carcinogenic potency in each species
• Original experimental results and test data are completely referenced
• Overview and Update of Analyses of the Carcinogenic Potency Database, including interpretation of positive results in cancer bioassays and ranking possible cancer hazards at average human exposure levels.

Table of Contents

Chapter 1
Carcinogenic Potency Database......................................................................p 1
Lois Swirsky Gold, Thomas H. Slone, Neela B. Manley, Georganne Backman Garfinkel, Lars Rohrbach
and Bruce N. Ames

        Section A: Methods of the Carcinogenic Potency Database....................................p 1
        Section B: Guide to the Plot of the Carcinogenic Potency Database..........................p 9
        Section C: Plot of Cancer Test Results.....................................................p 17
        Section D: Appendices of Codes and Definitions.............................................p 543
                Appendix 1: Species................................................................p 543
                Appendix 2: Strains................................................................p 545
                Appendix 3: Routes of Administration...............................................p 547
                Appendix 4: Site Codes.............................................................p 549
                Appendix 5: Histopathology of the Carcinogenic Potency Database....................p 551
                Appendix 6: Notecodes..............................................................p 555
                Appendix 7: Dose-Response Curve Symbols............................................p 557
                Appendix 8: Statistical Methods for Estimating TD50................................p 559
                Appendix 9: Author's Opinion.......................................................p 561
                Appendix 10: Berkeley Codes........................................................p 563
                Appendix 11: Journals..............................................................p 565
                Appendix 12: Synonyms for Chemicals in the Carcinogenic Potency Database...........p 567
        Section E: Carcinogenicity Bibliography....................................................p 573
                Part 1: Carcinogenicity Bibliography -- NCI/NTP Technical Reports..................p 573
                Part 2: Carcinogenicity Bibliography -- General Literature.........................p 577

Chapter 2
Summary of the Carcinogenic Potency Database by Target Organ.......................................p 607
Lois Swirsky Gold, Neela B. Manley, and Thomas H. Slone

Chapter 3
Summary of the Carcinogenic Potency Database by Chemical...........................................p 621
Lois Swirsky Gold, Thomas H. Slone, and Bruce N. Ames

        Section A: Summary of Chemical Carcinogenicity in Rats and Mice............................p 624
        Section B: Summary of Chemical Carcinogenicity in Hamsters.................................p 658
        Section C: Summary of Chemical Carcinogenicity in Nonhuman Primates and Dogs...............p 660

Chapter 4
Overview and Update of Analyses of the Carcinogenic Potency Database...............................p 661
Lois Swirsky Gold, Thomas H. Slone, and Bruce N. Ames

Chapter 5
Genotoxicity Database..............................................................................p 687
Errol Zeiger

        Section A: Description of Genotoxicity Tests...............................................p 687
        Section B: Table of Genotoxicity Results...................................................p 694
        Section C: Genotoxicity Bibliography.......................................................p 726

Chapter 6
Index of Chemical Names in the Carcinogenic Potency (CPDB) and Genotoxicity (GT) Databases
by Chemical Abstract Service (CAS) Registry Number.................................................p 731

To order, contact CRC Press at 1-800-272-77337 (phone) or 1-800-374-3401 (FAX).

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Last updated: August 6, 2007